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华大时空组学技术Stereo-seq已被成功应用到器官发生、胚胎发育、生命演化、脑科学、肿瘤等多个不同领域,证明了其普适性。未来,时空组学有望应用到生命科学与临床研究的各个领域,尤其疾病研究领域,最终为人类健康带来极大的改善。目前,已有120余篇Stereo-seq及其应用成果发表在CellNatureScience等国际顶级学术期刊。

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122条搜索结果:
Stereo-seq助力绘制全球首个阿尔茨海默病海马单细胞分辨率时空图谱

2025-03-31 DOI:10.1016/j.neuron.2025.03.002

Stereo-seq助力绘制全球首个阿尔茨海默病海马单细胞分辨率时空图谱

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期刊·Neuron 物种·人 样本类型·海马体
Single-cell spatial transcriptomic atlas of the whole mouse brain

2025-03-20 DOI: 10.1016/j.neuron.2025.02.015

Single-cell spatial transcriptomic atlas of the whole mouse brain

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期刊·Neuron 物种·大鼠 样本类型·大脑
Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

2025-03-19 DOI:10.1038/s41586-025-08757-x

Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

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期刊·Nature 物种·小鼠、猴子 样本类型·小鼠胚胎、猴子大脑
Integrative single-cell and spatial transcriptome analysis reveals heterogeneity of human liver progenitor cells

2025-03-01 DOI: 10.1097/HC9.0000000000000662

Integrative single-cell and spatial transcriptome analysis reveals heterogeneity of human liver progenitor cells

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期刊·Hepatology Communications 物种·人类 样本类型·肝脏
Single-nucleus profiling decoding the subcortical visual pathway evolution of vertebrates

2025-02-27 DOI: 10.1016/j.isci.2025.112128

Single-nucleus profiling decoding the subcortical visual pathway evolution of vertebrates

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期刊·iScience 物种·鸟类、哺乳类动物 样本类型·视顶盖样本
Stereo-seq助力绘制首个国产大豆的全生命周期器官发育“时空图谱”

2025-02-18 DOI: 10.1016/j.molp.2025.02.003

Stereo-seq助力绘制首个国产大豆的全生命周期器官发育“时空图谱”

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期刊·Molecular Plant 物种·大豆 样本类型·根、根瘤、茎尖、叶、茎
Cross-tissue multi-omics analyses reveal the gut microbiota'sabsence impacts organ morphology, immune homeostasis,bile acid and lipid metabolism

2025-02-14 DOI:10.1002/imt2.272

Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism

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期刊·iMeta 物种·小鼠
Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA-Seq and Stereo-Seq, with Insights into SOX3's Role in Pituitary Development

2025-02-14 DOI: 10.1002/advs.202414230

Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA-Seq and Stereo-Seq, with Insights into SOX3's Role in Pituitary Development

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期刊·Advanced Science  物种·人 样本类型·垂体器官
Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis

2025-02-10 DOI:10.1038/s41392-025-02143-9

Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis

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期刊·Signal transduction and targeted therapy 物种·小鼠 样本类型·暴发性心肌炎
推断细胞时空分化轨迹的新算法SpaTrack

2025-02-04 DOI: 10.1016/j.cels.2025.101194

推断细胞时空分化轨迹的新算法SpaTrack

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期刊·Cell Systems 物种·多物种 样本类型·多样本类型