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华大时空组学技术Stereo-seq已被成功应用到器官发生、胚胎发育、生命演化、脑科学、肿瘤等多个不同领域,证明了其普适性。未来,时空组学有望应用到生命科学与临床研究的各个领域,尤其疾病研究领域,最终为人类健康带来极大的改善。目前,已有150余篇Stereo-seq及其应用成果发表在CellNatureScience等国际顶级学术期刊。

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High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation

2025-05-29 DOI:10.1016/j.jid.2025.04.041

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation

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期刊·Journal of Investigative Dermatology 物种·人 样本类型·面部皮脂腺样本
StereoMM: a graph fusion model for integrating spatial tra nscriptomic data and pathological images

2025-05-23 DOI:10.1093/bib/bbaf210

StereoMM: a graph fusion model for integrating spatial tra nscriptomic data and pathological images

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期刊·Briefings in Bioinformatics 物种·人 样本类型·结直肠癌患者样本
Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution

2025-05-23 DOI: 10.1016/j.neuron.2025.04.026

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution

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期刊·Neuron 物种·小鼠 样本类型·脑出血后小鼠大脑样本
Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis

2025-05-22 DOI:10.1016/j.ard.2025.04.025

Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis

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期刊·Annals of the Rheumatic Diseases 物种·人 样本类型·例弥漫型皮肤系统性硬化症(SSc)患者样本
肺移植术后“72小时生死线”,Stereo-seq助力重症PGD找到新突破!

2025-05-20 DOI:10.1016/j.xcrm.2025.102140

肺移植术后“72小时生死线”,Stereo-seq助力重症PGD找到新突破!

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期刊·Cell Reports Medicine 物种·小鼠、大鼠 样本类型·小鼠肺缺血再灌注损伤(IRI)模型、大鼠左肺移植模型
Integrating Spatial and Single-Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

2025-05-19 DOI:10.1002/advs.202411126

Integrating Spatial and Single-Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

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期刊·Advanced Science 物种·母体孕前糖尿病条件下胎儿 样本类型·胰腺
Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging

2025-05-19 DOI:10.1186/s13073-025-01475-z

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging

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期刊· Genome Medicine 物种·人类 样本类型·角膜
Adv. Sci | 从“奋斗”到“躺平”?Stereo-seq助力揭示肝脏应对“虫癌”的免疫应答机制

2025-05-15 DOI:10.1002/advs.202405914

Adv. Sci | 从“奋斗”到“躺平”?Stereo-seq助力揭示肝脏应对“虫癌”的免疫应答机制

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期刊·Advanced science 物种·小鼠 样本类型·肝脏
Dev. Cell | Stereo-seq助力构建羊膜类跨物种单细胞图谱,解密3.2亿年大脑演化之谜

2025-05-15 DOI:0.1016/j.devcel.2025.04.014

Dev. Cell | Stereo-seq助力构建羊膜类跨物种单细胞图谱,解密3.2亿年大脑演化之谜

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期刊·Developmental Cell 物种·爬行动物、鸟类和哺乳类等 样本类型·大脑
DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis

2025-05-08 DOI:10.1073/pnas.2417445122

DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis

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期刊·PNAS 物种·斑马鱼 样本类型·胚胎血管