Stereo-seq应用_时空组学要解决的问题_Stereo-seq技术_STOmics - 华大时空

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华大时空组学技术Stereo-seq已被成功应用到器官发生、胚胎发育、生命演化、脑科学、肿瘤等多个不同领域，证明了其普适性。未来，时空组学有望应用到生命科学与临床研究的各个领域，尤其疾病研究领域，最终为人类健康带来极大的改善。目前，已有110余篇Stereo-seq及其应用成果发表在Cell、Nature、Science等国际顶级学术期刊。

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华大时空文章列表

Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

2025-03-19 DOI：10.1038/s41586-025-08757-x

Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

期刊·Nature 物种·小鼠、猴子样本类型·小鼠胚胎、猴子大脑

Stereo-seq助力绘制首个国产大豆的全生命周期器官发育“时空图谱”

2025-02-18 DOI: 10.1016/j.molp.2025.02.003

Stereo-seq助力绘制首个国产大豆的全生命周期器官发育“时空图谱”

期刊·Molecular Plant 物种·大豆样本类型·根、根瘤、茎尖、叶、茎

Cross-tissue multi-omics analyses reveal the gut microbiota'sabsence impacts organ morphology, immune homeostasis,bile acid and lipid metabolism

2025-02-14 DOI：10.1002/imt2.272

Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism

期刊·iMeta 物种·小鼠

Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA-Seq and Stereo-Seq, with Insights into SOX3's Role in Pituitary Development

2025-02-14 DOI: 10.1002/advs.202414230

Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA-Seq and Stereo-Seq, with Insights into SOX3's Role in Pituitary Development

期刊·Advanced Science 物种·人样本类型·垂体器官

推断细胞时空分化轨迹的新算法SpaTrack

2025-02-04 DOI: 10.1016/j.cels.2025.101194

推断细胞时空分化轨迹的新算法SpaTrack

期刊·Cell Systems 物种·多物种样本类型·多样本类型

Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization

2025-02-03 DOI: 10.1038/s41467-025-56501-w

Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization

期刊· Nature Communications 物种·小鼠样本类型·肺

A single-cell and spatial wheat root atlas with cross-species annotations delineates conserved tissue-specific marker genes and regulators

2025-02-01 DOI：10.1016/j.celrep.2025.115240

A single-cell and spatial wheat root atlas with cross-species annotations delineates conserved tissue-specific marker genes and regulators

期刊·Cell Reports 物种·小麦样本类型·根组织

2025-01-28 DOI：10.1038/s41421-024-00747-z

Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma

期刊·Cell Discovery 物种·人样本类型·肝部

2025-01-21 DOI：10.1016/j.xcrm.2024.101914

High cellular plasticity state of medulloblastoma local recurrence and distant dissemination

期刊·Cell Reports Medicine 物种·人样本类型·小脑

2025-01-21 DOI：10.1186/s12943-025-02231-y

Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases

期刊·Molecular Cancer 物种·人样本类型·结直肠

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